Limb Ischemia
The Crisis of Limb Ischemic Diseases
The prevalence and associated costs of Peripheral Arterial Disease (PAD) - a condition where the arteries in the limbs, typically the legs, become narrowed or blocked by atherosclerosis, or plaque buildup that reduces the flow of blood in peripheral arteries - and Chronic Limb Ischemia (CLI) - which is an advanced form of PAD - is substantial and alarming.
200M
Estimated # of people globally with Peripheral Arterial Disease (PAD) (NIH).
414B
PAD-related Costs Per Year
900K
New Chronic Limb Ischemia (CLI) Patients Per Year
200B
CLI-related Costs Per Year
Peripheral Arterial Disease (PAD) and Chronic Limb Ischemia (CLI)
Left: Gangrene of the big toe - a complication of severe PAD
Right: Post surgical changes. Residual PAD-related symptoms including nail dystrophy, thin, shiny skin and ischemic atrophy in other toes remain.
COMMON PAD SYMPTOMS INCLUDE:
- Cold, pale, or bluish feet, weak or absent pulse in the legs, muscle atrophy.
WORSENING SYMPTOMS ASSOCIATED WITH CLI INCLUDE:
- Rest pain: Persistent or reoccurring pain (claudication) in the foot, toes, or leg, that is typically worse at night effecting sleep.
- Non-healing ulcers: Open sores or wounds on the toe, foot or lower leg that fail to heal.
- Gangrene: Tissue death (necrosis) on the toe, or foot, often appearing black, dry, or infected.
In this recent study, we re-examined the data of the Phase II clinical treatment of no option Critical limb ischemia with Hemostemix’ angiogenic cell precursors, focusing upon ulcer wound healing, amputation and death rate of this cohort.
